Virus meets host
The evidence connects viral RNA structure, mitophagy, entry co-factors, iron-linked receptor abundance, infected-cell trafficking, and Dicer–Ago2 antiviral RNAi.
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Viral
Viral
pathogenesis
Identifying viral structures and host pathways that govern entry, survival, susceptibility, spread, and restriction.
Evidence map04
Cells, piglets, sows, birds
PRRSV infectious clones, porcine epithelial systems, newborn piglets, sow–colostrum–neonate transmission, avian macrophages, and SPF chickens.
Perturb every layer
Clone rescue, gene silencing, receptor blocking, signaling and endocytosis perturbation, iron manipulation, animal challenge, cell tracking, small-RNA mapping, and nucleic-acid intervention.
Intervention points across scales
Targets appear in viral RNA, entry machinery, host metabolism, stress control, cell trafficking, and sequence-specific RNA defense.
Independent editorial synthesis · reviewed 7 September 2026
ORCID 0000-0002-2349-0028 · NJAU College of Veterinary Medicine
Representative evidence
Six papers selected for conceptual importance and temporal coverage. They are examples, not a substitute for the complete reconciled bibliography.
Cis-acting structural element in 5 ' UTR is essential for infectivity of porcine reproductive and respiratory syndrome virus
In PRRSV infectious-clone experiments, the proximal 5′-UTR stem-loop structure—not a fixed primary sequence—was consistently required for infectivity.
Official bibliography role: Correspondence AuthorFei Gao, Jiaqi Lu, Huochun Yao, Zuzhang Wei, Qian Yang, Shishan Yuan Open source record · DOI 10.1016/j.virusres.2011.08.018 ↗
Mitophagy in TGEV infection counteracts oxidative stress and apoptosis
TGEV-induced DJ-1-associated mitophagy limited oxidative stress and apoptosis in porcine cells; the net effect in animals was not established.
Verified paper role: Correspondence AuthorLiqi Zhu, Chunxiao Mou, Xing Yang, Jian Lin, Qian Yang Open source record · DOI 10.18632/oncotarget.8345 ↗
Epidermal growth factor receptor is a co-factor for transmissible gastroenteritis virus entry
EGFR acted with APN and entry-linked signaling as a TGEV co-factor; it was not proposed as a replacement for the known receptor.
Official bibliography role: Correspondence AuthorWeiwei Hu, Shuai Zhang, Yumeng Shen, Qian Yang Open source record · DOI 10.1016/j.virol.2018.05.009 ↗
Transferrin receptor 1 levels at the cell surface influence the susceptibility of newborn piglets to PEDV infection
High apical TfR1 and iron deficiency increased PEDV susceptibility in neonatal and cell models, identifying an age-linked entry mechanism rather than a treatment recommendation.
Official bibliography role: Correspondence AuthorShuai Zhang, Yanan Cao, Qian Yang Open source record · DOI 10.1371/journal.ppat.1008682 ↗
A Novel Pathway for Porcine Epidemic Diarrhea Virus Transmission from Sows to Neonatal Piglets Mediated by Colostrum
The study supports infected T-cell movement from sow intestine through blood and mammary tissue into colostrum, without estimating its population-level share of transmission.
Official bibliography role: Correspondence AuthorYuan C, Zhang P, Liu P, Li Y, Li J, Zhang E, Jin Y, Yang Q Open source record · DOI 10.1128/jvi.00477-22 ↗
Virus-derived siRNA: Coronavirus and influenza virus trigger antiviral RNAi immunity in birds
Wild-type avian coronavirus and influenza infection generated Dicer–Ago2 antiviral vsiRNAs; the proposed therapeutic-vaccine route remains experimental.
Official bibliography role: Participating authorsYaotang Wu, Peng Liu, Jie Zhou, Mei R. Fu, Chenlu Wang, Ningna Xiong, Wei Ji, Zhisheng Wang, Jian Lin, Qian Yang Open source record · DOI 10.1093/nar/gkaf116 ↗
Read as a program,
not a priority claim.
These overlapping themes are an editorial synthesis of the publication record. They do not claim sole scientific ownership, clinical validation, regulatory approval, or independent replication. Titles and bibliographic facts come from the reconciled record; explanatory summaries are constrained to the cited evidence.
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